Homologous recombination: ends as the means

被引：53

作者：

Ray, A

Langer, M

机构：

[1] Keck Grad Inst, Claremont, CA 91711 USA

[2] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

来源：

TRENDS IN PLANT SCIENCE | 2002年 / 7卷 / 10期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1360-1385(02)02327-0

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Broken chromosomal ends in somatic cells of higher plants frequently heal by the ligation of DNA ends to unrelated sequences or to sequences with micro-homologies. This pathway of DNA-strand-break repair is the bane of gene-targeting attempts in plants. However, there is a second somatic pathway of chromosome repair, which is driven by DNA-sequence homology. Observations from yeast, fly and plants of homologous-recombination mechanisms point towards new strategies of gene targeting in plants.

引用

收藏

页码：435 / 440

页数：6

相关论文

共 56 条

[1]

ATHMA P, 1991, GENETICS, V128, P163

[2] Clustering of meiotic double-strand breaks on yeast chromosome III [J].

Baudat, F ;

Nicolas, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (10) :5213-5218

[3]

Bennett CB, 1996, MOL CELL BIOL, V16, P4414

[4] Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdfl/Hdf2 complexes [J].

Chen, L ;

Trujillo, K ;

Ramos, W ;

Sung, P ;

Tomkinson, AE .

MOLECULAR CELL, 2001, 8 (05) :1105-1115

[5] Enhancement of somatic intrachromosomal homologous recombination in Arabidopsis by the HO endonuclease [J].

Chiurazzi, M ;

Ray, A ;

Viret, JF ;

Perera, R ;

Wang, XH ;

Lloyd, AM ;

Signer, ER .

PLANT CELL, 1996, 8 (11) :2057-2066

[6]

Clikeman JA, 2001, GENETICS, V157, P579

[7] A SOMATIC GENE REARRANGEMENT CONTRIBUTING TO GENETIC DIVERSITY IN MAIZE [J].

DAS, OP ;

LEVIMINZI, S ;

KOURY, M ;

BENNER, M ;

MESSING, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (20) :7809-7813

[8] REGION-SPECIFIC ACTIVATORS OF MEIOTIC RECOMBINATION IN SCHIZOSACCHAROMYCES-POMBE [J].

DEVEAUX, LC ;

SMITH, GR .

GENES & DEVELOPMENT, 1994, 8 (02) :203-210

[9] Extensive interallelic polymorphisms drive meiotic recombination into a crossover pathway [J].

Dooner, HK .

PLANT CELL, 2002, 14 (05) :1173-1183

[10] ENHANCED MITOTIC RECOMBINATION IN A LIGASE-DEFECTIVE MUTANT OF THE YEAST SACCHAROMYCES-CEREVISIAE [J].

GAME, JC ;

JOHNSTON, LH ;

BORSTEL, RCV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (09) :4589-4592

← 1 2 3 4 5 6 →