Homologous recombination: ends as the means

被引：53

作者：

Ray, A

Langer, M

机构：

[1] Keck Grad Inst, Claremont, CA 91711 USA

[2] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

来源：

TRENDS IN PLANT SCIENCE | 2002年 / 7卷 / 10期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1360-1385(02)02327-0

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Broken chromosomal ends in somatic cells of higher plants frequently heal by the ligation of DNA ends to unrelated sequences or to sequences with micro-homologies. This pathway of DNA-strand-break repair is the bane of gene-targeting attempts in plants. However, there is a second somatic pathway of chromosome repair, which is driven by DNA-sequence homology. Observations from yeast, fly and plants of homologous-recombination mechanisms point towards new strategies of gene targeting in plants.

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收藏

页码：435 / 440

页数：6

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