Cysteine dioxygenase: modulation of expression in human cell lines by cytokines and control of sulphate production

被引：20

作者：

Wilkinson, LJ ^{[1
]}

Waring, RH ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

TOXICOLOGY IN VITRO | 2002年 / 16卷 / 04期

关键词：

cysteine dioxygenase; sulfate; cytokine; TNF-alpha; human cell lines;

D O I：

10.1016/S0887-2333(02)00031-0

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Cysteine dioxygenase (CDO) is the initial and rate-limiting enzyme involved in the oxidative degradation of cysteine to inorganic sulphate. It is believed to be the major source of sulphate in vivo. Inflammatory conditions such as rheumatoid arthritis have been linked with high plasma cysteine:sulphate ratios in patients. The cytokines tumour necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) have been shown to inhibit the expression of CDO in neuronal (TE671) and hepatic (Chang) human cell lines at nanomolar concentrations. Cytokine release may therefore modulate sulphate production and hence regulate formation of sulphated biocomponents. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：481 / 483

页数：3