Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays

被引：60

作者：

Yan, Ming

Zhang, Lu-Yong

Sun, Li-Xin

Jiang, Zhen-Zhou

Xiao, Xiao-He

机构：

[1] China Pharmaceut Univ, Natl Drug Screening Lab, Nanjing 210038, Jiangsu Prov, Peoples R China

[2] PLA 302 Hosp, Beijing 100039, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2006年 / 107卷 / 02期

关键词：

total rhubarb anthroquinones; oligonucleotide microarrays; toxicogenomics;

D O I：

10.1016/j.jep.2006.03.031

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Total rhubarb anthraquinones (TRAs) are the active therapeutic components from the rhizomes of Rheum palmatum L. (Polygonaceae), which are widely used in traditional Chinese medicines (TCMs) and have been reported to have cell toxicity recently. This study focuses on the toxicity of TRAs on Sprague Dawley (S.D.) rats. TRAs administrated per os for 13 weeks induced nephrotoxicity on S.D. rats as renal tubule epithelial cells swelled and denatured in tissue slice examination. After high-density oligonucleotide microarrays scanning, we have identified mitogen-activated protein kinase (MAPK) kinase 6 to be the target gene which causes cell cycle arrest and proliferation inhibition and contributes to nephrotoxicity on S.D. rats. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：308 / 311

页数：4

共 13 条

[1] Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production [J].