The alpha- and beta-tubulin folding pathways

被引:135
作者
Lewis, SA
Tian, GL
Cowan, NJ
机构
[1] Dept. of Biochemistry, NYU Medical Center, New York
关键词
D O I
10.1016/S0962-8924(97)01168-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The alpha-beta tubulin heterodimer is the subunit from which microtubules are assembled. The pathway leading to correctly folded alpha- and beta-tubulins is unusually complex: it involves cycles of ATP-dependent interaction of newly synthesized tubulin subunits with cytosolic chaperonin, resulting in the production of quasi-native folding intermediates, which must then be acted upon by additional protein cofactors. These cofactors for a supercomplex containing both alpha- and beta-tubulin polypeptides, from which native heterodimer is released in a GTP-dependent reaction. Here, we discuss the current state our understanding of the function of cytosolic chaperonin and cofactors in tubulin folding.
引用
收藏
页码:479 / 484
页数:6
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