Cell death occurs in plants as a part of normal development and as a response to toxins, pathogens and other environmental stimuli or insults. When cell death occurs as an orderly disassembly of the cell under the control of a genetically determined program, the process is referred to as programmed cell death (PCD). The PCD mechanisms of plants show many striking similarities to, but also intriguing differences from, those of animals. The extensive genetic, developmental and physiological characterizations of maize have made it an excellent system for the study of cell death. We describe the recent advances in the study of cell death in maize in light of what is known in plants and animals.