A new synthetic route to 10β-alkyldeoxoartemisinins

被引：17

作者：

Ma, JY

Katz, E

Ziffer, H ^{[1
]}

机构：

[1] NIDDK, Chem Phys Lab, Bethesda, MD 20892 USA

[2] NIDDK, Bioorgan Chem Lab, Bethesda, MD 20892 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 49期

关键词：

artemisinin; lactol acetate; trimethyloxy group; titanium tetrachloride;

D O I：

10.1016/S0040-4039(99)01824-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Artemisinin was reduced with DIBAL and acetylated to yield 10 alpha-acetoxyartemisinin. The latter compound was treated with titanium tetrachloride and a series of trimethylsiloxyl enol ethers to produce a series of 10 beta-alkyldeoxoartemisinins. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：8543 / 8545

页数：3

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