Synthesis of cytochrome c oxidase models bearing a Tyr244 mimic

被引：33

作者：

Collman, JP ^{[1
]}

Decréau, RA ^{[1
]}

Zhang, C ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 10期

关键词：

D O I：

10.1021/jo0499625

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A close structural analogue of the metal-free cytochrome c oxidase active site has been synthesized. This model has a proximal imidazole tail and three distal imidazole pickets attached to a porphyrin. One distal imidazole is cross-linked to a phenol, mimicking Tyr(244). The strategy behind the successful synthesis of this regioisomerically pure model involved discovering the best sequence to introduce the phenol-substituted imidazole and employing a fluorinated substituent.

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页码：3546 / 3549

页数：4

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