Vasoactive intestinal peptide attenuates cytochrome c translocation, and apoptosis, in rat hippocampal stem cells

被引：14

作者：

Antonawich, FJ

Said, SI

机构：

[1] SUNY Stony Brook, Dept Neurol, Stony Brook, NY 11794 USA

[2] Northport DVA Med Ctr, Northport, NY 11768 USA

[3] SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA

[4] SUNY Stony Brook, Dept Physiol, Stony Brook, NY 11794 USA

[5] SUNY Stony Brook, Dept Pharmacol, Stony Brook, NY 11794 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 325卷 / 03期

关键词：

progenitor cell; pituitary adenylate cyclase activating peptide; PACAP cytochrome c;

D O I：

10.1016/S0304-3940(02)00254-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

While widely distributed in the brain, one area with concentrated levels of vasoactive intestinal peptide (VIP) is the hippocampus. In this study, rat hippocampal stem cells were used to examine VIP's effects on apoptotic cell death induced by withdrawal of trophic support. In the apoptotic cascade, the translocation of cytochrome c from the mitochondria to the cytoplasm activates caspases, resulting in cell death. VIP decreased this translocation of cytochrome c in a dose-dependent manner, and reduced apoptosis. This demonstrates that VIP regulates neuronal apoptosis and may contribute to stem cell homeostasis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：151 / 154

页数：4

共 25 条

[21] Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization [J].