Assaying neurotransmitters in and around single neurons with information-rich detectors

被引：16

作者：

Dahlgren, RL

Page, JS

Sweedler, JV

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[2] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA

来源：

ANALYTICA CHIMICA ACTA | 1999年 / 400卷

关键词：

single cell assay; capillary separations; capillary electrophoresis; mass spectrometry; MALDI; ESI;

D O I：

10.1016/S0003-2670(99)00606-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Techniques to study the chemical environment in and around individual neurons are reviewed, with an emphasis on methods to assay single cells for neurotransmitters and neuromodulators that do not require analyte preselection. Current capabilities of capillary-based microseparations and mass spectrometry are highlighted for this application. Methods to combine multiple analytical techniques to provide chemical, spatial and temporal information are described. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：13 / 26

页数：14

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