Serotonin-2A receptor polymorphism (102T/C) in mood disorders

被引：41

作者：

Tsai, SJ

Hong, CJ

Hsu, CC

Cheng, CY

Liao, WY

Song, HL

Lai, HC

机构：

[1] Vet Gen Hosp Taipei, Dept Psychiat, Taipei 11217, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan

[3] Tao Yuan Vet Hosp, Taipei, Taiwan

来源：

PSYCHIATRY RESEARCH | 1999年 / 87卷 / 2-3期

关键词：

genetics; association study; polymorphism; 5HT(2A) receptor; mood disorders; suicide;

D O I：

10.1016/S0165-1781(99)00059-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Serotonergic dysfunction has been implicated in mood disorders and suicidal behaviors. This study examined the association between a serotonin-2A (5HT(2A)) receptor gene polymorphism (102T/C) and mood disorders. The genotype and allele frequencies did not differ between patients with mood disorders and control subjects. Furthermore, the 102T/C polymorphism was not found to be associated with suicidal history in mood disorder patients. Our results suggest that this polymorphism is unlikely to play a role in the genetic susceptibility to mood disorders. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：233 / 237

页数：5

共 14 条

[1]

[Anonymous], 1994, Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV), V4th

[2]

ARORA RC, 1989, AM J PSYCHIAT, V146, P730

[3] 5-HT2A receptor and bipolar affective disorder: Association studies in affected patients [J].

Arranz, MJ ;

Erdmann, J ;

Kirov, G ;

Rietschel, M ;

Sodhi, M ;

Albus, M ;

Ball, D ;

Maier, W ;

Davies, N ;

Franzek, E ;

Abusaad, I ;

Weigelt, B ;

Murray, R ;

ShimronAbarbanell, D ;

Kerwin, R ;

Propping, P ;

Sham, P ;

Nothen, MM ;

Collier, DA .

NEUROSCIENCE LETTERS, 1997, 224 (02) :95-98

[4] SEROTONIN 5-HT2 RECEPTOR-BINDING ON BLOOD-PLATELETS AS A STATE DEPENDENT MARKER IN MAJOR AFFECTIVE-DISORDER [J].

BIEGON, A ;

ESSAR, N ;

ISRAELI, M ;

ELIZUR, A ;

BRUCH, S ;

BARNATHAN, AA .

PSYCHOPHARMACOLOGY, 1990, 102 (01) :73-75

[5] Lack of allelic association between 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia in Chinese [J].

Chen, CH ;

Lee, YR ;

Wei, FC ;

Koong, FJ ;

Hwu, HG ;

Hsiao, KJ .

PSYCHIATRIC GENETICS, 1997, 7 (01) :35-38

[6] SPECT IMAGING OF SEROTONIN(2) RECEPTORS IN DEPRESSION [J].

DHAENEN, H ;

BOSSUYT, A ;

MERTENS, J ;

BOSSUYTPIRON, C ;

GIJSEMANS, M ;

KAUFMAN, L .

PSYCHIATRY RESEARCH-NEUROIMAGING, 1992, 45 (04) :227-237

[7] 5HT(1A) RECEPTOR GENE AND BIPOLAR AFFECTIVE-DISORDER [J].

GUTIERREZ, B ;

ARRANZ, M ;

FANANAS, L ;

VALLES, V ;

GUILLAMAT, R ;

VANOS, J ;

COLLIER, D .

LANCET, 1995, 346 (8980) :969-969

[8] No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism [J].

Mahieu, B ;

Souery, D ;

Lipp, O ;

Mendelbaum, K ;

Verheyen, G ;

DeMaertelaer, V ;

Van Broeckhoven, C ;

Mendlewicz, J .

PSYCHIATRY RESEARCH, 1997, 70 (02) :65-69

[9]

MANN JJ, 1986, ARCH GEN PSYCHIAT, V43, P954

[10] 5-HT RECEPTOR-BINDING IN POSTMORTEM BRAIN FROM PATIENTS WITH AFFECTIVE-DISORDER [J].

MCKEITH, IG ;

MARSHALL, EF ;

FERRIER, IN ;

ARMSTRONG, MM ;

KENNEDY, WN ;

PERRY, RH ;

PERRY, EK ;

ECCLESTON, D .

JOURNAL OF AFFECTIVE DISORDERS, 1987, 13 (01) :67-74

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