Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

被引：206

作者：

Perry, John R. B. ^{[1
,2
]}

Stolk, Lisette ^{[1
,3
]}

Franceschini, Nora ^{[4
]}

Lunetta, Kathryn L. ^{[5
,6
]}

Zhai, Guangju ^{[7
]}

McArdle, Patrick F. ^{[8
]}

Smith, Albert V. ^{[9
]}

Aspelund, Thor ^{[9
,10
]}

Bandinelli, Stefania ^{[11
]}

Boerwinkle, Eric ^{[12
]}

Cherkas, Lynn ^{[7
]}

Eiriksdottir, Gudny ^{[9
]}

Estrada, Karol ^{[1
]}

Ferrucci, Luigi ^{[13
]}

Folsom, Aaron R. ^{[14
]}

Garcia, Melissa ^{[15
]}

Gudnason, Vilmundur ^{[9
,10
]}

Hofman, Albert ^{[3
]}

Karasik, David ^{[5
,16
,17
]}

Kiel, Douglas P. ^{[5
,16
,17
]}

Launer, Lenore J. ^{[15
]}

van Meurs, Joyce ^{[1
]}

Nalls, Michael A. ^{[2
,18
]}

Rivadeneira, Fernando ^{[1
,3
]}

Shuldiner, Alan R. ^{[8
]}

Singleton, Andrew ^{[18
]}

Soranzo, Nicole ^{[7
,19
]}

Tanaka, Toshiko ^{[20
]}

Visser, Jenny A. ^{[1
]}

Weedon, Michael N.

Wilson, Scott G. ^{[7
,21
,22
]}

Zhuang, Vivian ^{[6
]}

Streeten, Elizabeth A. ^{[8
]}

Harris, Tamara B. ^{[15
]}

Murray, Anna ^{[2
]}

Spector, Tim D. ^{[7
]}

Demerath, Ellen W. ^{[14
]}

Uitterlinden, Andre G. ^{[1
,3
]}

Murabito, Joanne M. ^{[5
,23
]}

机构：

[1] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[2] Penn Med Sch, Inst Biomed & Clin Sci, Exeter, Devon, England

[3] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[4] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA

[5] Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA

[6] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[7] Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England

[8] Univ Maryland, Sch Med, Div Endocrinol Diabet Clin Nutr, Baltimore, MD 21201 USA

[9] Iceland Heart Assoc, Kopavogur, Iceland

[10] Univ Iceland, Reykjavik, Iceland

[11] Azienda Sanitaria Firenze, Geriatr Unit, Florence, Italy

[12] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX USA

[13] NIA, Clin Res Branch, Longitudinal Studies Sect, Baltimore, MD 21224 USA

[14] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[15] NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[16] Hebrew SeniorLife Inst Aging Res, Boston, MA USA

[17] Harvard Univ, Sch Med, Boston, MA USA

[18] NIA, Neurogenet Lab, Bethesda, MD 20892 USA

[19] Wellcome Trust Sanger Inst, Hinxton, Cambs, England

[20] NIA, Medstar Res Inst, Baltimore, MD 21224 USA

[21] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia

[22] Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA 6009, Australia

[23] Boston Univ, Sch Med, Dept Med, Gen Internal Med Sect, Boston, MA 02118 USA

来源：

NATURE GENETICS | 2009年 / 41卷 / 06期

基金：

英国惠康基金;

关键词：

SECULAR TRENDS; OBESITY; GIRLS; ADULTHOOD; HEIGHT; GROWTH; GENES;

D O I：

10.1038/ng.386

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 x 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 x 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

引用

页码：648 / 650

页数：3

共 15 条

[1] A genome-wide linkage scan for age at menarche in three populations of European descent [J].

Anderson, Carl A. ;

Zhu, Gu ;

Falchi, Mario ;

van den Berg, Stephanie M. ;

Treloar, Susan A. ;

Spector, Timothy D. ;

Martin, Nicholas G. ;

Boomsma, Dorret I. ;

Visscher, Peter M. ;

Montgomery, Grant W. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (10) :3965-3970

[2] Relative weight and race influence average age at menarche: Results from two nationally representative surveys of US girls studied 25 years apart [J].

Anderson, SE ;

Dallal, GE ;

Must, A .

PEDIATRICS, 2003, 111 (04) :844-850

[3] Reliability of data on medical conditions, menstrual and reproductive history provided by hospital controls [J].

Bosetti, C ;

Tavani, A ;

Negri, E ;

Trichopoulos, D ;

La Vecchia, C .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 2001, 54 (09) :902-906

[4] Examination of US puberty-timing data from 1940 to 1994 for secular trends: Panel findings [J].

Euling, Susan Y. ;

Herman-Giddens, Marcia E. ;

Lee, Peter A. ;

Selevan, Sherry G. ;

Juul, Anders ;

Sorensen, Thorkild I. A. ;

Dunkel, Leo ;

Himes, John H. ;

Teilmann, Grete ;

Swan, Shanna H. .

PEDIATRICS, 2008, 121 :S172-S191

[5] Association Studies of Common Variants in 10 Hypogonadotropic Hypogonadism Genes with Age at Menarche [J].

Gajdos, Zofia K. Z. ;

Butler, Johannah L. ;

Henderson, Katherine DeLellis ;

He, Chunyan ;

Supelak, Pamela J. ;

Egyud, Matthew ;

Price, Alkes ;

Reich, David ;

Clayton, Peter E. ;

Le Marchand, Loic ;

Hunter, David J. ;

Henderson, Brian E. ;

Palmert, Mark R. ;

Hirschhorn, Joel N. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (11) :4290-4298

[6] MATURATIONAL TIMING AS A FACTOR IN FEMALE FATNESS AND OBESITY [J].

GARN, SM ;

LAVELLE, M ;

ROSENBERG, KR ;

HAWTHORNE, VM .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1986, 43 (06) :879-883

[7] Age at Menarche in the Canadian Population: Secular Trends and Relationship to Adulthood BMI [J].

Harris, M. Anne ;

Prior, Jerilynn C. ;

Koehoom, Mieke .

JOURNAL OF ADOLESCENT HEALTH, 2008, 43 (06) :548-554

[8] Identification of ten loci associated with height highlights new biological pathways in human growth [J].

Lettre, Guillaume ;

Jackson, Anne U. ;

Gieger, Christian ;

Schumacher, Fredrick R. ;

Berndt, Sonja I. ;

Sanna, Serena ;

Eyheramendy, Susana ;

Voight, Benjamin F. ;

Butler, Johannah L. ;

Guiducci, Candace ;

Illig, Thomas ;

Hackett, Rachel ;

Heid, Iris M. ;

Jacobs, Kevin B. ;

Lyssenko, Valeriya ;

Uda, Manuela ;

Boehnke, Michael ;

Chanock, Stephen J. ;

Groop, Leif C. ;

Hu, Frank B. ;

Isomaa, Bo ;

Kraft, Peter ;

Peltonen, Leena ;

Salomaa, Veikko ;

Schlessinger, David ;

Hunter, David J. ;

Hayes, Richard B. ;

Abecasis, Goncalo R. ;

Wichmann, H-Erich ;

Mohlke, Karen L. ;

Hirschhorn, Joel N. .

NATURE GENETICS, 2008, 40 (05) :584-591

[9] VARIATIONS IN PATTERN OF PUBERTAL CHANGES IN GIRLS [J].

MARSHALL, WA ;

TANNER, JM .

ARCHIVES OF DISEASE IN CHILDHOOD, 1969, 44 (235) :291-+

[10] Age at menarche in relation to adult height [J].

Onland-Moret, NC ;

Peeters, PHM ;

van Gils, CH ;

Clavel-Chapelon, F ;

Key, T ;

Tjonneland, A ;

Trichopoulou, A ;

Kaaks, R ;

Manjer, J ;

Panico, S ;

Palli, D ;

Tehard, B ;

Stoikidou, M ;

Bueno-De-Mesquita, HB ;

Boeing, H ;

Overvad, K ;

Lenner, P ;

Quirós, JR ;

Chirlaque, MD ;

Miller, AB ;

Khaw, KT ;

Riboli, E .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2005, 162 (07) :623-632

← 1 2 →