Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

被引：206

作者：

Perry, John R. B. ^{[1
,2
]}

Stolk, Lisette ^{[1
,3
]}

Franceschini, Nora ^{[4
]}

Lunetta, Kathryn L. ^{[5
,6
]}

Zhai, Guangju ^{[7
]}

McArdle, Patrick F. ^{[8
]}

Smith, Albert V. ^{[9
]}

Aspelund, Thor ^{[9
,10
]}

Bandinelli, Stefania ^{[11
]}

Boerwinkle, Eric ^{[12
]}

Cherkas, Lynn ^{[7
]}

Eiriksdottir, Gudny ^{[9
]}

Estrada, Karol ^{[1
]}

Ferrucci, Luigi ^{[13
]}

Folsom, Aaron R. ^{[14
]}

Garcia, Melissa ^{[15
]}

Gudnason, Vilmundur ^{[9
,10
]}

Hofman, Albert ^{[3
]}

Karasik, David ^{[5
,16
,17
]}

Kiel, Douglas P. ^{[5
,16
,17
]}

Launer, Lenore J. ^{[15
]}

van Meurs, Joyce ^{[1
]}

Nalls, Michael A. ^{[2
,18
]}

Rivadeneira, Fernando ^{[1
,3
]}

Shuldiner, Alan R. ^{[8
]}

Singleton, Andrew ^{[18
]}

Soranzo, Nicole ^{[7
,19
]}

Tanaka, Toshiko ^{[20
]}

Visser, Jenny A. ^{[1
]}

Weedon, Michael N.

Wilson, Scott G. ^{[7
,21
,22
]}

Zhuang, Vivian ^{[6
]}

Streeten, Elizabeth A. ^{[8
]}

Harris, Tamara B. ^{[15
]}

Murray, Anna ^{[2
]}

Spector, Tim D. ^{[7
]}

Demerath, Ellen W. ^{[14
]}

Uitterlinden, Andre G. ^{[1
,3
]}

Murabito, Joanne M. ^{[5
,23
]}

机构：

[1] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[2] Penn Med Sch, Inst Biomed & Clin Sci, Exeter, Devon, England

[3] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[4] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA

[5] Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA

[6] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[7] Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England

[8] Univ Maryland, Sch Med, Div Endocrinol Diabet Clin Nutr, Baltimore, MD 21201 USA

[9] Iceland Heart Assoc, Kopavogur, Iceland

[10] Univ Iceland, Reykjavik, Iceland

[11] Azienda Sanitaria Firenze, Geriatr Unit, Florence, Italy

[12] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX USA

[13] NIA, Clin Res Branch, Longitudinal Studies Sect, Baltimore, MD 21224 USA

[14] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[15] NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[16] Hebrew SeniorLife Inst Aging Res, Boston, MA USA

[17] Harvard Univ, Sch Med, Boston, MA USA

[18] NIA, Neurogenet Lab, Bethesda, MD 20892 USA

[19] Wellcome Trust Sanger Inst, Hinxton, Cambs, England

[20] NIA, Medstar Res Inst, Baltimore, MD 21224 USA

[21] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia

[22] Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA 6009, Australia

[23] Boston Univ, Sch Med, Dept Med, Gen Internal Med Sect, Boston, MA 02118 USA

来源：

NATURE GENETICS | 2009年 / 41卷 / 06期

基金：

英国惠康基金;

关键词：

SECULAR TRENDS; OBESITY; GIRLS; ADULTHOOD; HEIGHT; GROWTH; GENES;

D O I：

10.1038/ng.386

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 x 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 x 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

引用

页码：648 / 650

页数：3

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