Ubiquitin signalling: what's in a chain?

被引：22

作者：

Hochstrasser, M ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 07期

关键词：

D O I：

10.1038/ncb0704-571

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

When cellular proteins are attached to a Lys 48-linked polyubiquitin chain, the proteasome will usually degrade them. But attaching such a chain to a yeast transcription factor inhibits its activity without degradation, raising questions about how polyubiquitination regulates transcriptional activation and why the protein is spared destruction.

引用

页码：571 / 572

页数：2

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