The Emerging Biomolecular Role of Vitamin D in Skeletal Muscle

被引：100

作者：

Pojednic, Rachele M. ^{[1
]}

Ceglia, Lisa ^{[2
,3
]}

机构：

[1] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA

[2] Tufts Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA USA

[3] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Bone Metab Lab, Boston, MA 02111 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2014年 / 42卷 / 02期

关键词：

skeletal muscle; 25-hydroxyvitamin D; aging; vitamin D receptor; vitamin D; D-RECEPTOR GENE; KAPPA-B ACTIVITY; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; 1,25-DIHYDROXYVITAMIN D-3; MYOGENIC DIFFERENTIATION; CALCIUM SUPPLEMENTATION; 25-HYDROXYVITAMIN D; GROWTH-FACTORS; EXPRESSION; STRENGTH;

D O I：

10.1249/JES.0000000000000013

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

In this review, we summarize current evidence for a direct effect of vitamin D on skeletal muscle. A number of studies identify the receptor for 1,25-dihydroxyvitamin-D-3 (vitamin D receptor (VDR)) and the enzyme CYP27B1 (1-alpha-hydroxylase) in muscle. We hypothesize that vitamin D acts on myocytes via the VDR, and we examine proposed effects on myocyte proliferation, differentiation, growth, and inflammation.

引用

页码：76 / 81

页数：6

共 48 条

[41]

Vitamin D Increases Cellular Turnover and Functionally Restores the Skeletal Muscle after Crush Injury in Rats [J].