Deep brain stimulation:: Neuropsychological and neuropsychiatric issues

被引：274

作者：

Voon, V

Kubu, C

Krack, P

Houeto, JL

Tröster, AI

机构：

[1] NINDS, Human Motor Control Sect, NIH, Bethesda, MD 20892 USA

[2] Toronto Western Hosp, Dept Psychiat, Toronto, ON M5T 2S8, Canada

[3] Cleveland Clin Fdn, Dept Psychiat & Psychol, Cleveland, OH 44195 USA

[4] Univ Grenoble, Dept Neurol, Grenoble, France

[5] Univ Grenoble, INSERM, U318, Grenoble, France

[6] Univ Poitiers Hosp, Dept Neurol, Poitiers, France

[7] Univ N Carolina, Sch Med, Dept Neurol, Chapel Hill, NC USA

来源：

MOVEMENT DISORDERS | 2006年 / 21卷

关键词：

Parkinson's disease; deep brain stimulation; depression; cognition; subthalamic;

D O I：

10.1002/mds.20963

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor, cognitive, neuropsychiatric, autonomic, and other nonmotor symptoms. The efficacy of deep brain stimulation (DBS) for the motor symptoms of advanced PD is well established. However, the effects of DBS on the cognitive and neuropsychiatric symptoms are less clear. The neuropsychiatric aspects of DBS for PD have recently been of considerable clinical and pathophysiological interest. As a companion to the preoperative and postoperative sections of the DBS consensus articles, this article reviews the published literature on the cognitive and neuropsychiatric aspects of DBS for PD. The majority of the observed neuropsychiatric symptoms are transient, treatable, and potentially preventable. Outcome studies, methodological issues, pathophysiology, and preoperative and postoperative management of the cognitive and neuropsychiatric aspects and complications of DBS for PD are discussed. (C) 2006 Movement Disorder Society.

引用

页码：S305 / S327

页数：23

共 157 条

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