Supramolecular control of oligosaccharide-protein interactions: Switchable and tunable ligands for concanavalin A based on cyclodextrin

被引：47

作者：

Smiljanic, Nicolas

Moreau, Vincent

Yockot, Duplex

Benito, Juan M.

Fernandez, Jose M. Garcia

Djedaini-Pilard, Florence

机构：

[1] Univ Seville, CSIC, Inst Invest Quim, Seville 41092, Spain

[2] Univ Picardie Jules Verne, Lab Glucides, UMR 6219, F-80039 Amiens, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 33期

关键词：

carbohydrates; cyclodextrins; lectins; noncovalent interactions; receptors;

D O I：

10.1002/anie.200601123

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ins and outs of binding: Supramolecular control of carbohydrate-protein interactions has been achieved through the design of β-cyclodextrin (βCD) based conjugates whose conformation is dependent on a reversible self-inclusion process. The accessibility of glycoligands to the lectin binding site is then regulated by allosteric inclusion of effector/antagonist-like molecules in the βCD cavity (see scheme). (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5465 / 5468

页数：4

共 44 条

[1] Structural effects of oligosaccharide-branched cyclodextrins on the dual recognition toward lectin and drug [J].