Cholesteryl-cyclodextrins:: synthesis and insertion into phospholipid membranes

被引：52

作者：

Auzély-Velty, R

Perly, B

Taché, O

Zemb, T

Jéhan, P

Guenot, P

Dalbiez, JP

Djedaïni-Pilard, F

机构：

[1] CEA Saclay, DRECAM, Serv Chim Mol, F-91191 Gif Sur Yvette, France

[2] Univ Rennes 1, CRMPO, F-35042 Rennes, France

来源：

CARBOHYDRATE RESEARCH | 1999年 / 318卷 / 1-4期

关键词：

amphiphilic cyclodextrins; phospholipid bilayers; NMR spectroscopy; X-ray scattering;

D O I：

10.1016/S0008-6215(99)00086-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

6(I)-(Cholest-5-en-3 beta-yloxycarbonyl)amino-6(1w)-deoxycyclomaltoheptaose and 6(I)-(cholest-5-en-3 alpha-ylamido)succinylamido-6(I)-deoxycyclomaltoheptaose were synthesized and fully characterized by NMR spectroscopy experiments and mass spectrometry analysis. Incorporation of these monosubstituted amphiphilic cyclodextrins into phospholipid bilayers was investigated using small-angle X-ray scattering, differential scanning calorimetry and P-31 nuclear magnetic resonance. Different modes of incorporation depending on the spacer length between the cyclodextrin and cholesterol moieties were observed. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：82 / 90

页数：9

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