Microbiological transformations .37. An enantioconvergent synthesis of the beta-blocker (R)-Nifenalol(R) using a combined chemoenzymatic approach

被引：82

作者：

PedragosaMoreau, S ^{[1
]}

Morisseau, C ^{[1
]}

Baratti, J ^{[1
]}

Zylber, J ^{[1
]}

Archelas, A ^{[1
]}

Furstoss, R ^{[1
]}

机构：

[1] FAC SCI LUMINY,GRP BIOCATALYSE & CHIM FINE,ERS 157 CNRS,F-13288 MARSEILLE,FRANCE

来源：

TETRAHEDRON | 1997年 / 53卷 / 28期

关键词：

D O I：

10.1016/S0040-4020(97)00639-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work describes the synthesis of (R)-Nifenalol(R) based on an enantioconvergent chemoenzymatic hydrolysis of para-nitrostyrene oxide. A mathematical approach is devised which allowed to optimize the process. (C) 1997 Elsevier Science Ltd.

引用

页码：9707 / 9714

页数：8

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