Stereoconvergent synthesis of (2S,3S,8S,9S,4E,6E)-N-Boc-ADDA starting from (S)-serine and (S)-phenyllactic acid

被引：35

作者：

DAniello, F

Mann, A

Schoenfelder, A

Taddei, M

机构：

[1] CNRS,CTR NEUROCHIM,UPR 421,LAB PHARMACOCHIM MOL,F-67084 STRASBOURG,FRANCE

[2] UNIV SASSARI,DIPARTIMENTO CHIM,I-07100 SASSARI,ITALY

来源：

TETRAHEDRON | 1997年 / 53卷 / 04期

关键词：

D O I：

10.1016/S0040-4020(96)01056-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The important naturally occurring beta-amino acid N-Boc-ADDA is prepared following a disconnection of the C-C bond between the two E,E double bonds. The stereochemistry of the two synthons was controlled using the alkylation of chiral bromoalienes derived from naturally occurring (S)-serine and (S)-phenyllactic acid. The cupration of bromoallenes derived from (S)-serine also provides a general method for the synthesis of chiral beta-alkylated aspartic acid derivatives. (C) 1997, Elsevier Science Ltd.

引用

页码：1447 / 1456

页数：10

共 23 条

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