Hydrophilic multi-walled carbon nanotubes decorated with magnetite nanoparticles as lymphatic targeted drug delivery vehicles

被引：136

作者：

Yang, Dong ^{[1
]}

Yang, Feng ^{[2
]}

Hu, Jianhua ^{[1
]}

Long, Jiang ^{[2
]}

Wang, Changchun ^{[1
]}

Fu, Deliang ^{[2
]}

Ni, Quanxing ^{[2
]}

机构：

[1] Fudan Univ, Key Lab Mol Engn Polymers, Minist Educ, Dept Macromol Sci,Adv Mat Lab, Shanghai 200433, Peoples R China

[2] Fudan Univ, Pancreat Dis Inst, Dept Surg, Huashan Hosp, Shanghai 200040, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 29期

基金：

美国国家科学基金会; 中国博士后科学基金;

关键词：

SINGLE-WALL; BREAST-CANCER; WATER; BIODISTRIBUTION; POLYMERIZATION; DISPERSIONS; MICE; DNA;

D O I：

10.1039/b908012k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrophilic multi-walled carbon nanotubes decorated with magnetite nanoparticles were readily taken up into lymph vessels and delivered gemcitabine to lymph nodes with high efficiency under the guidance of a magnetic field.

引用

页码：4447 / 4449

页数：3

共 28 条

[1] Biomedical applications of functionalised carbon nanotubes [J].

Bianco, A ;

Kostarelos, K ;

Partidos, CD ;

Prato, M .

CHEMICAL COMMUNICATIONS, 2005, (05) :571-577

[2] Applications of carbon nanotubes in drug delivery [J].

Bianco, A ;

Kostarelos, K ;

Prato, M .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (06) :674-679

[3] Dispersion of pristine single-walled carbon nanotubes in water by a thiolated organosilane: Application in supramolecular nanoassemblies [J].

Bottini, Massimo ;

Magrini, Andrea ;

Rosato, Nicola ;

Bergamaschi, Antonio ;

Mustelin, Tomas .

JOURNAL OF PHYSICAL CHEMISTRY B, 2006, 110 (28) :13685-13688

[4]

CARR I, 1983, CANCER METAST REV, V2, P307, DOI 10.1007/BF00048483

[5] Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells [J].

Dumortier, Helene ;

Lacotte, Stephanie ;

Pastorin, Giorgia ;

Marega, Riccardo ;

Wu, Wei ;

Bonifazi, Davide ;

Briand, Jean-Paul ;

Prato, Maurizio ;

Muller, Sylviane ;

Bianco, Alberto .

NANO LETTERS, 2006, 6 (07) :1522-1528

[6] Formation of single-wall carbon nanotube superbundles [J].

Gennett, T ;

Dillon, AC ;

Alleman, JL ;

Jones, KM ;

Hasoon, FS ;

Heben, MJ .

CHEMISTRY OF MATERIALS, 2000, 12 (03) :599-+

[7] Synthesis of nickel-nitrilotriacetic acid coupled single-walled carbon nanotubes for directed self-assembly with polyhistidine-tagged proteins [J].

Graff, Rachel A. ;

Swanson, Thomas M. ;

Strano, Michael S. .

CHEMISTRY OF MATERIALS, 2008, 20 (05) :1824-1829

[8] Selective drug delivery to peri-tumoral region and regional lymphatics by local injection of aclarubicin adsorbed on activated carbon particles in patients with breast cancer - a pilot study [J].

Hagiwara, A ;

Takahashi, T ;

Sawai, K ;

Sakakura, C ;

Shirasu, M ;

Ohgaki, M ;

Imanishi, T ;

Yamasaki, J ;

Takemoto, Y ;

Kageyama, N .

ANTI-CANCER DRUGS, 1997, 8 (07) :666-670

[9] Synthesis of water-soluble multiwalled carbon nanotubes with grafted temperature-responsive shells by surface RAFT polymerization [J].

Hong, CY ;

You, YZ ;

Pan, CY .

CHEMISTRY OF MATERIALS, 2005, 17 (09) :2247-2254

[10] HELICAL MICROTUBULES OF GRAPHITIC CARBON [J].

IIJIMA, S .

NATURE, 1991, 354 (6348) :56-58

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