Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas

被引：88

作者：

Sarkaria, Inderpal

O-charoenrat, Pornchai

Talbot, Simon G.

Reddy, Pabbathi G.

Ngai, Ivan

Maghami, Ellie

Patel, Kepal N.

Lee, Benjamin

Yonekawa, Yoshihiro

Dudas, Maria

Kaufman, Andrew

Ryan, Russell

Ghossein, Ronald

Rao, Pulivarthi H.

Stoffel, Archontoula

Ramanathan, Y.

Singh, Bhuvanesh

机构：

[1] Mem Sloan Kettering Canc Ctr, Lab Epithelial Canc Biol, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Head & Neck Serv, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Thorac Surg Serv, New York, NY 10021 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[5] Rockefeller Univ, Canc Biol Lab, New York, NY 10021 USA

[6] Baylor Coll Med, Childrens Canc Ctr, Houston, TX 77030 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 19期

关键词：

D O I：

10.1158/0008-5472.CAN-06-2074

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosomal amplification at 3q is common to multiple human cancers, but has a specific predilection for squamous cell carcinomas (SCC) of mucosal origin. We identified and characterized a novel oncogene, SCC-related oncogene (SCCRO), which is amplified along the 3q26.3 region in human SCC. Amplification and overexpression of SCCRO in these tumors correlate with poor clinical outcome. The importance of SCCRO amplification in malignant transformation is established by the apoptotic response to short hairpin RNA against SCCRO, exclusively in cancer cell lines carrying SCCRO amplification. The oncogenic potential of SCCRO is underscored by its ability to transform fibroblasts (NIH-3T3 cells) in vitro and in vivo. We show that SCCRO regulates Gli1 -a key regulator of the hedgehog (HH) pathway. Collectively, these data suggest that SCCRO is a novel component of the HH signaling pathway involved in the malignant transformation of squamous cell lineage.

引用

页码：9437 / 9444

页数：8

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