Therapeutic Interventions for Frail Elderly Patients: Part II. Ongoing and Unpublished Randomized Trials

被引：48

作者：

Bendayan, Melissa ^{[1
]}

Bibas, Lior ^{[2
,3
]}

Levi, Michael ^{[2
,3
]}

Mullie, Louie ^{[2
]}

Forman, Daniel E. ^{[4
,5
]}

Afilalo, Jonathan ^{[2
,3
,6
,7
]}

机构：

[1] McGill Univ, Dept Physiol, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Med, Montreal, PQ H3T 1E2, Canada

[3] McGill Univ, Div Cardiol, Montreal, PQ H3T 1E2, Canada

[4] Univ Pittsburgh, Med Ctr, Sect Geriatr Cardiol, Pittsburgh, PA USA

[5] VA Pittsburgh Healthcare Syst, Geratr Res Educ & Clin Ctr, Pittsburgh, PA USA

[6] McGill Univ, Jewish Gen Hosp, Div Cardiol, Montreal, PQ H3T 1E2, Canada

[7] McGill Univ, Jewish Gen Hosp, Div Clin Epidemiol, Montreal, PQ H3T 1E2, Canada

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2014年 / 57卷 / 02期

关键词：

Frailty; Sarcopenia; Randomized clinical trials; MUSCLE STRENGTH; OLDER-ADULTS; SARCOPENIA; MEN; SUPPLEMENTATION; METAANALYSIS; EXERCISE; HEALTH; PEOPLE;

D O I：

10.1016/j.pcad.2014.07.005

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

There is increasing momentum to measure frailty in clinical practice given its proven value as a predictor of outcomes, particularly in elderly patients with cardiovascular disease. The number of randomized clinical trials targeting frail older adults has been modest to date. Therefore, we systematically searched the ClinicalTrials.gov registry in order to review the frailty intervention trials that had been actively initiated or completed but not yet published. The interventions studied were exercise training in 2 trials, nutritional supplementation in 3 trials, combined exercise plus nutritional supplementation in 5 trials, pharmaceutical agents in 5 trials, multidimensional programs in 2 trials, and home-based services in 3 trials. Their respective study designs, populations, interventions, and planned outcomes are presented in this article. (c) 2014 Elsevier Inc. All rights reserved.

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收藏

页码：144 / 151

页数：8

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