Recent advances with recombinant bacterial vaccine vectors

被引：98

作者：

Shata, MT ^{[1
]}

Stevceva, L ^{[1
]}

Agwale, S ^{[1
]}

Lewis, GK ^{[1
]}

Hone, DM ^{[1
]}

机构：

[1] Inst Human Virol, Div Vaccine Res, Baltimore, MD 21201 USA

来源：

MOLECULAR MEDICINE TODAY | 2000年 / 6卷 / 02期

关键词：

D O I：

10.1016/S1357-4310(99)01633-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacille Calmette-Guerin (BCG), Listeria monocytogenes, Salmonellae and Shigellae have shown promise as vaccine vectors in experimental animal models, Although disappointing results in humans and nonhuman primates stalled the development of this vaccination strategy, interest in this approach was reinvigorated recently by the development of bacterial DNA-vaccine-vectors. The purpose of this review is to highlight the strengths and weaknesses of bacterial vaccine vectors, and to discuss the future prospects of these vaccine delivery systems.

引用

页码：66 / 71

页数：6

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