SAFETY AND IMMUNOGENICITY OF SALMONELLA-TYPHI TY21A VACCINE IN YOUNG THAI CHILDREN

被引：46

作者：

CRYZ, SJ

VANPRAPAR, N

THISYAKORN, U

OLANRATMANEE, T

LOSONSKY, G

LEVINE, MM

CHEARSKUL, S

机构：

[1] MAHIDOL UNIV, SIRIRAJ HOSP, FAC MED, DEPT PEDIAT, BANGKOK 10700, THAILAND

[2] MINIST PUBL HLTH, CHACHOENGSAO HOSP, CHACHOENGSAO, THAILAND

[3] CHULALONGKORN UNIV, FAC MED, DEPT PEDIAT, BANGKOK 5, THAILAND

[4] UNIV MARYLAND, SCH MED, CTR VACCINE DEV, BALTIMORE, MD 21201 USA

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 03期

关键词：

D O I：

10.1128/IAI.61.3.1149-1151.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Salmonella typhi Ty21a vaccine in a liquid formulation was evaluated in 634 Thai children 2 to 6 years of age. The seroconversion rate was 69% for those who received vaccine versus 14% for those who received placebo (P < 0.005). The immune responses among vaccine recipients ranged from 60% in 3-year-olds to 81% for 6-year-olds.

引用

页码：1149 / 1151

页数：3

共 13 条

[1] EPIDEMIC MULTIRESISTANT ENTERIC FEVER IN EASTERN-INDIA [J].

ANAND, AC ;

KATARIA, VK ;

SINGH, W ;

CHATTERJEE, SK .

LANCET, 1990, 335 (8685) :352-352

[2]

BLACK R, 1982, DEV BIOLOGICALS, V53, P9

[3]

EDELMAN R, 1986, REV INFECT DIS, V8, P329

[4] MULTIRESISTANT SALMONELLA-TYPHI IN INDIA [J].

JESUDASAN, MV ;

JOHN, TJ .

LANCET, 1990, 336 (8709) :252-252

[5] SAFETY, INFECTIVITY, IMMUNOGENICITY, AND INVIVO STABILITY OF 2 ATTENUATED AUXOTROPHIC MUTANT STRAINS OF SALMONELLA-TYPHI, 541TY AND 543TY, AS LIVE ORAL VACCINES IN HUMANS [J].

LEVINE, MM ;

HERRINGTON, D ;

MURPHY, JR ;

MORRIS, JG ;

LOSONSKY, G ;

TALL, B ;

LINDBERG, AA ;

SVENSON, S ;

BAQAR, S ;

EDWARDS, MF ;

STOCKER, B .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (03) :888-902

[6]

LEVINE MM, 1987, LANCET, V1, P1049

[7]

LEVINE MM, 1990, LANCET, V336, P891

[8]

LEVINE MM, 1989, REV INFECT DIS, V11, pS552

[9] IMMUNOGENICITY OF SALMONELLA-TYPHI TY21A VACCINE FOR YOUNG-CHILDREN [J].

MURPHY, JR ;

GREZ, L ;

SCHLESINGER, L ;

FERRECCIO, C ;

BAQAR, S ;

MUNOZ, C ;

WASSERMAN, SS ;

LOSONSKY, G ;

OLSON, JG ;

LEVINE, MM .

INFECTION AND IMMUNITY, 1991, 59 (11) :4291-4293

[10] CHARACTERISTICS OF HUMORAL AND CELLULAR-IMMUNITY TO SALMONELLA-TYPHI IN RESIDENTS OF TYPHOID-ENDEMIC AND TYPHOID-FREE REGIONS [J].

MURPHY, JR ;

BAQAR, S ;

MUNOZ, C ;

SCHLESINGER, L ;

FERRECCIO, C ;

LINDBERG, AA ;

SVENSON, S ;

LOSONSKY, G ;

KOSTER, F ;

LEVINE, MM .

JOURNAL OF INFECTIOUS DISEASES, 1987, 156 (06) :1005-1009

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