The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection

被引：117

作者：

Hauber, Ilona ^{[1
]}

Hohenberg, Heinrich ^{[1
]}

Holstermann, Barbara ^{[1
]}

Hunstein, Werner ^{[2
]}

Hauber, Joachim ^{[1
]}

机构：

[1] Heinrich Pette Inst Expt Virol & Immunol, D-20251 Hamburg, Germany

[2] Heidelberg Univ, Fac Med, D-69118 Heidelberg, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 22期

基金：

美国国家卫生研究院;

关键词：

EGCG; microbicide; prostatic acidic phosphatase; SEVI; sexual transmission; IMMUNODEFICIENCY-VIRUS TYPE-1; GALLATE; TRANSMISSION; ACTIVATION; DISEASES; THERAPY; BINDS; CD4;

D O I：

10.1073/pnas.0811827106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Peptide fragments, derived from prostatic acidic phosphatase, are secreted in large amounts into human semen and form amyloid fibrils. These fibrillar structures, termed semen-derived enhancer of virus infection (SEVI), capture HIV virions and direct them to target cells. Thus, SEVI appears to be an important infectivity factor of HIV during sexual transmission. Here, we are able to demonstrate that epigallocatechin-3-gallate (EGCG), the major active constituent of geen tea, targets SEVI for degradation. Furthermore, it is shown that EGCG inhibits SEVI activity and abrogates semen-mediated enhancement of HIV-1 infection in the absence of cellular toxicity. Therefore, EGCG appears to be a promising supplement to antiretroviral microbicides to reduce sexual transmission of HIV-1.

引用

页码：9033 / 9038

页数：6

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