Sirtuins: guardians of mammalian healthspan

被引：282

作者：

Giblin, William ^{[1
]}

Skinner, Mary E. ^{[2
]}

Lombard, David B. ^{[2
,3
]}

机构：

[1] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Inst Gerontol, Ann Arbor, MI 48109 USA

来源：

TRENDS IN GENETICS | 2014年 / 30卷 / 07期

基金：

美国国家卫生研究院;

关键词：

aging; longevity; age-associated disease; NAD(+); mitochondria; SIRT1; SIRT3; SIRT6; EXTENDS LIFE-SPAN; FATTY-ACID OXIDATION; STIMULATED INSULIN-SECRETION; HISTONE DEACETYLASE SIRT6; NF-KAPPA-B; CALORIE RESTRICTION; CAENORHABDITIS-ELEGANS; DIETARY RESTRICTION; C; ELEGANS; PYRUVATE-DEHYDROGENASE;

D O I：

10.1016/j.tig.2014.04.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

The first link between sirtuins and longevity was made 15 years ago in yeast. These initial studies sparked efforts by many laboratories working in diverse model organisms to elucidate the relations between sirtuins, lifespan, and age-associated dysfunction. Here, we discuss the current understanding of how sirtuins relate to aging. We focus primarily on mammalian sirtuins SIRT1, SIRT3, and SIRT6, the three sirtuins for which the most relevant data are available. Strikingly, a large body of evidence now indicates that these and other mammalian sirtuins suppress a variety of age-related pathologies and promote healthspan. Moreover, increased expression of SIRT1 or SIRT6 extends mouse lifespan. Overall, these data point to important roles for sirtuins in promoting mammalian health, and perhaps in modulating the aging process.

引用

收藏

页码：271 / 286

页数：16

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