Screening of nerve agent degradation products by MALDI-TOFMS

被引：22

作者：

Shu, You-Ren

Su, An-Kai

Liu, Ju-Tsung

Lin, Cheng-Huang

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, Taipei, Taiwan

[2] Mil Police Command, Dept Def, Forens Sci Ctr, Taipei, Taiwan

来源：

ANALYTICAL CHEMISTRY | 2006年 / 78卷 / 13期

关键词：

D O I：

10.1021/ac060007k

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel method for the rapid screening of degradation products derived from nerve agents by matrix-assisted laser desorption ionization time-of-flight mass spectrometry is described. Five standard products were selected as model compounds, including isopropyl methylphosphonic acid ( IMPA), pinacolyl methylphosphonic acid ( PMPA), ethyl methylphosphonic acid (EMPA), isobutyl methylphosphonic acid (i-BuMPA), and cyclohexyl methylphosphonic acid (CHMPA), which are degradation products of Sarin ( GB), Soman (GD), VX, Russian VX (RVX), and GF, respectively. For comparison, CHCA (alpha-cyano4-hydroxycinnamic acid) and DCCA (7-( diethylamino) coumarin-3-carboxylic acid) were used as the MALDI-matrix when the third harmonic generation ( 355 nm) of a Nd: YAG laser and a hydrogen Raman laser (multifrequency laser) were used, respectively. The method permitted the five nerve agent degradation products to be screened rapidly and successfully, suggesting that it has the potential for use as a routine monitoring tool.

引用

收藏

页码：4697 / 4701

页数：5

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