Tracing the pathway of spindle assembly checkpoint signaling

被引：22

作者：

Gillett, ES ^{[1
]}

Sorger, PK ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

DEVELOPMENTAL CELL | 2001年 / 1卷 / 02期

关键词：

D O I：

10.1016/S1534-5807(01)00032-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1.

引用

收藏

页码：162 / 164

页数：3

相关论文

共 11 条

[1] Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint [J].

Abrieu, A ;

Magnaghi-Jaulin, L ;

Kahana, JA ;

Peter, M ;

Castro, A ;

Vigneron, S ;

Lorca, T ;

Cleveland, DW ;

Labbé, JC .

CELL, 2001, 106 (01) :83-93

[2] The spindle checkpoint [J].

Amon, A .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (01) :69-75

[3] Complexity in the spindle checkpoint [J].

Burke, DJ .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (01) :26-31

[4] Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC [J].

Chan, GKT ;

Jablonski, SA ;

Sudakin, V ;

Hittle, JC ;

Yen, TJ .

JOURNAL OF CELL BIOLOGY, 1999, 146 (05) :941-954

[5] Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2 [J].

Dobles, M ;

Liberal, V ;

Scott, ML ;

Benezra, R ;

Sorger, PK .

CELL, 2000, 101 (06) :635-645

[6] The mouse Mps1p-like kinase regulates centrosome duplication [J].

Fisk, HA ;

Winey, M .

CELL, 2001, 106 (01) :95-104

[7] Regulation of the APC and the exit from mitosis [J].

Morgan, DO .

NATURE CELL BIOLOGY, 1999, 1 (02) :E47-E53

[8] Waiting for anaphase: Mad2 and the spindle assembly checkpoint [J].

Shah, JV ;

Cleveland, DW .

CELL, 2000, 103 (07) :997-1000

[9] Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints [J].

Skoufias, DA ;

Andreassen, PR ;

Lacroix, FB ;

Wilson, L ;

Margolis, RL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4492-4497

[10] Mad2-independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1 [J].

Tang, ZY ;

Bharadwaj, R ;

Li, B ;

Yu, HT .

DEVELOPMENTAL CELL, 2001, 1 (02) :227-237