p-toluenesulfonic acid catalyzed regiospecific nitration of phenols with metal nitrates

被引：87

作者：

Anuradha, V. ^{[1
]}

Srinivas, P. V. ^{[1
]}

Aparna, P. ^{[1
]}

Rao, J. Madhusudana ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 28期

关键词：

nitration; nickel nitrate; regiospecific; p-TSA;

D O I：

10.1016/j.tetlet.2006.05.017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly regiospecific mononitration of phenols and substituted phenols is accomplished employing a metal nitrate and a catalytic amount of p-toluenesulfonic acid in acetone. An exclusive ortho-selectivity was observed with excellent yields. A variety of metal nitrates were used to obtain o-nitrophenois exclusively in good to excellent yields. The use of p-toluenesulfonic acid is key for the selectivity observed. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4933 / 4935

页数：3

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