Coherent Activation of DNA Tweezers: A "SET-RESET" Logic System

被引:134
作者
Elbaz, Johann [1 ]
Moshe, Michal [1 ]
Willner, Itamar [1 ]
机构
[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel
关键词
aptamers; DNA machines; logic gates; molecular devices; tweezers; MACHINE; APTAMER; RELEASE; DEVICES; DNAZYME; PROTEIN; ENZYME; IONS;
D O I
10.1002/anie.200805819
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Open sesame: Aptamer-substrate complexes activate the coherent operation of two tweezers that act as a "SET-RESET" logic system. Each tweezer cycles between a fluorescent open state and a closed quenched state (Q=quencher, F=fluorophore) when triggered by adenosine monophosphate (AMP) and adenosine deaminase (AD). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:3834 / 3837
页数:4
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