Discovery of potent CRTh2 (DP2) receptor antagonists

被引：36

作者：

Birkinshaw, Timothy N.

Teague, Simon J.

Beech, Claire

Bonnert, Roger V.

Hill, Stephen

Patel, Anil

Reakes, Sara

Sanganee, Hitesh

Dougall, Iain G.

Phillips, Tim T.

Salter, Sylvia

Schmidt, Jerzy

Arrowsmith, Elizabeth C.

Carrillo, Juan J.

Bell, Fiona M.

Paine, Stuart W.

Weaver, Richard

机构：

[1] AstraZeneca R&D Charnwood, Dept Med Chem, Loughborough LE11 5RH, Leics, England

[2] AstraZeneca R&D Charnwood, Dept Biol Mol, Loughborough LE11 5RH, Leics, England

[3] AstraZeneca R&D Charnwood, Dept Discovery Biosci, Loughborough LE11 5RH, Leics, England

[4] AstraZeneca R&D Charnwood, Dept Phys & Metab Sci, Loughborough LE11 5RH, Leics, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 16期

关键词：

CRTh2; DP2; inflammation; asthma; indomethacin; indole; quinoline;

D O I：

10.1016/j.bmcl.2006.05.062

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP2) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4287 / 4290

页数：4

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