Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function

被引:108
作者
Cermakian, N [1 ]
Whitmore, D [1 ]
Foulkes, NS [1 ]
Sassone-Corsi, P [1 ]
机构
[1] Univ Strasbourg 1, Inst Natl Sante & Rech Med, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch, France
关键词
D O I
10.1073/pnas.97.8.4339
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Most clock genes encode transcription factors that interact to elicit cooperative control of clock function. Using a two-hybrid system approach, we have isolated two different partners of zebrafish (zf) CLOCK, which are similar to the mammalian BMAL1 (brain and muscle arylhydrocarbon receptor nuclear translocator-like protein 1), The two homologs, zfBMAL1 and zfBMAL2, contain conserved basic helix-loop-helix-PAS (Period-Arylhydrocarbon receptor-Singleminded) domains but diverge in the carboxyl termini, thus bearing different transcriptional activation potential. As for zf-Clock, the expression of both zfBmals oscillates in most tissues in the animal. However, in many tissues, the peak, levels, and kinetics of expression are different between the two genes and for the same gene from tissue to tissue. These results support the existence of independent peripheral oscillators and suggest that zfBMAL1 and zfBMAL2 may exert distinct circadian functions, interacting differentially with zfCLOCK at various times in different tissues. Our findings also indicate that multiple controls may be exerted by the central clock and/or that peripheral oscillators can differentially interpret central clock signals.
引用
收藏
页码:4339 / 4344
页数:6
相关论文
共 40 条
  • [21] Circadian rhythms in olfactory responses of Drosophila melanogaster
    Krishnan, B
    Dryer, SE
    Hardin, PE
    [J]. NATURE, 1999, 400 (6742) : 375 - 378
  • [22] Free running circadian rhythms of melatonin, luteinizing hormone, and cortisol in Syrian hamsters bearing the circadian tau mutation
    Lucas, RJ
    Stirland, JA
    Darrow, JM
    Menaker, M
    Loudon, ASI
    [J]. ENDOCRINOLOGY, 1999, 140 (02) : 758 - 764
  • [23] TRANSCRIPTIONAL RESPONSE TO CAMP IN BRAIN - SPECIFIC DISTRIBUTION AND INDUCTION OF CREM ANTAGONISTS
    MELLSTROM, B
    NARANJO, JR
    FOULKES, NS
    LAFARGA, M
    SASSONECORSI, P
    [J]. NEURON, 1993, 10 (04) : 655 - 665
  • [24] Evolution of circadian organization in vertebrates
    Menaker, M
    Moreira, LF
    Tosini, G
    [J]. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1997, 30 (03) : 305 - 313
  • [25] Antiphase circadian expression between BMAL1 and period homologue mRNA in the suprachiasmatic nucleus and peripheral tissues of rats
    Oishi, K
    Sakamoto, K
    Okada, T
    Nagase, T
    Ishida, N
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 253 (02) : 199 - 203
  • [26] Independent photoreceptive circadian clocks throughout Drosophila
    Plautz, JD
    Kaneko, M
    Hall, JC
    Kay, SA
    [J]. SCIENCE, 1997, 278 (5343) : 1632 - 1635
  • [27] CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless
    Rutila, JE
    Suri, V
    Le, M
    So, WV
    Rosbash, M
    Hall, JC
    [J]. CELL, 1998, 93 (05) : 805 - 814
  • [28] Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain
    Sakamoto, K
    Nagase, T
    Fukui, H
    Horikawa, K
    Okada, T
    Tanaka, H
    Sato, K
    Miyake, Y
    Ohara, O
    Kako, K
    Ishida, N
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (42) : 27039 - 27042
  • [29] Mammalian circadian autoregulatory loop:: A timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription
    Sangoram, AM
    Saez, L
    Antoch, MP
    Gekakis, N
    Staknis, D
    Whiteley, A
    Fruechte, EM
    Vitaterna, MH
    Shimomura, K
    King, DP
    Young, MW
    Weitz, CJ
    Takahashi, JS
    [J]. NEURON, 1998, 21 (05) : 1101 - 1113
  • [30] Molecular clocks: Mastering time by gene regulation
    Sassone-Corsi, P
    [J]. NATURE, 1998, 392 (6679) : 871 - +