Effect of photodynamic therapy in combination with mitomycin C on a mitomycin-resistant bladder cancer cell line

被引：31

作者：

Datta, SN ^{[1
]}

Allman, R ^{[1
]}

Loh, C ^{[1
]}

Mason, M ^{[1
]}

Matthews, PN ^{[1
]}

机构：

[1] VELINDRE HOSP, CTR CANC RES, CARDIFF CF4 7XL, S GLAM, WALES

来源：

BRITISH JOURNAL OF CANCER | 1997年 / 76卷 / 03期

关键词：

photochemotherapy; 5-aminolaevulinic acid; neoplasm; bladder; mitomycin C; drug resistance;

D O I：

10.1038/bjc.1997.384

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy is a method for treating cancer using drugs activated by light. A new compound, 5-aminolaevulinic acid (ALA), is a precursor of the active photosensitizer protoporphyrin IX (PpIX) and has fewer side-effects and much more transient phototoxicity than previous photosensitizers. Cell survival of ALA-mediated photodynamic therapy was measured in the J82 bladder cancer cell line, along with its mitomycin C-resistant counterpart J82/MMC. This demonstrated that mitomycin resistance is not cross-resistant to photodynamic therapy. There was also a suggestion that the mitomycin-resistant cells were more susceptible to photodynamic therapy than the parent cell line. Photodynamic therapy appeared to enhance the effect of mitomycin C, when mitomycin C was given first. This phenomenon was apparent for both drug-resistant and drug-sensitive cell lines. This suggests a possible role for combined mitomycin C and photodynamic therapy in superficial bladder tumours that have recurred despite intravesical cytotoxic drug treatment.

引用

页码：312 / 317

页数：6

共 34 条

[31]

SOMMERVILLE JJF, 1985, BR J UROL, V57, P586

[32]

STAR WM, 1986, CANCER RES, V46, P2532

[33] EFFECT OF INTRAVESICAL MITOMYCIN-C ON RECURRENCE OF NEWLY DIAGNOSED SUPERFICIAL BLADDER-CANCER - INTERIM-REPORT FROM THE MEDICAL-RESEARCH COUNCIL SUBGROUP ON SUPERFICIAL BLADDER-CANCER (UROLOGICAL CANCER WORKING PARTY) [J].

TOLLEY, DA ;

HARGREAVE, TB ;

SMITH, PH ;

WILLIAMS, JL ;

GRIGOR, KM ;

PARMAR, MKB ;

FREEDMAN, LS ;

USCINSKA, BM .

BRITISH MEDICAL JOURNAL, 1988, 296 (6639) :1759-1761

[34] CHARACTERIZATION OF A HUMAN BLADDER-CANCER CELL-LINE SELECTED FOR RESISTANCE TO MITOMYCIN-C [J].

XU, BH ;

GUPTA, V ;

SINGH, SV .

INTERNATIONAL JOURNAL OF CANCER, 1994, 58 (05) :686-692

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