Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis

被引：102

作者：

Chen, Y. ^{[1
,6
]}

Wang, T. ^{[2
,3
]}

Guan, M. ^{[2
,3
]}

Zhao, W. ^{[1
]}

Leung, F-K-L. ^{[1
,4
]}

Pan, H. ^{[2
,3
]}

Cao, X. ^{[2
,3
,5
]}

Guo, X. E. ^{[2
,3
,6
]}

Lu, W. W. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Human Tissue & Organs Degenerat, Beijing, Peoples R China

[3] Chinese Acad Sci, Shenzhen Key Lab Marine Biomed Mat, Beijing, Peoples R China

[4] Univ Hong Kong, Shenzhen Hosp, Shenzhen Key Lab Innovat Technol Orthopaed Trauma, Hong Kong, Hong Kong, Peoples R China

[5] Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD USA

[6] Columbia Univ, Dept Biomed Engn, Bone Bioengn Lab, New York, NY USA

来源：

OSTEOARTHRITIS AND CARTILAGE | 2015年 / 23卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Osteoarthritis; Subchondral bone cyst; Bone remodeling; Bone structure; Articular cartilage; MESENCHYMAL STEM-CELLS; HIP OSTEOARTHRITIS; CANCELLOUS BONE; ASSOCIATION; MRI; MICROSTRUCTURE; ARTHROPLASTY; OSSIFICATION; REPLACEMENT; PROGRESSION;

D O I：

10.1016/j.joca.2015.07.012

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Objective: To investigate changes in bone structure, turnover, and articular cartilage localized in subchondral bone cyst (SBC) regions associated with knee osteoarthritis (OA). Methods: Tibial plateaus (n = 97) were collected from knee OA patients during total knee arthroplasty (TKA). SBCs were identified using micro-computed tomography, and the specimens were divided into non-cyst (n = 25) and bone cyst (n = 72) groups. Microstructure of subchondral bone was assessed using bone volume fraction (BV/TV), trabecular number (Tb.N), structure model index (SMI) and bone mineral density (BMD). In bone cyst group, the cyst subregion, which contained at least one cyst, and the peri-cyst subregion, which contained no cysts, were further selected for microstructure analysis. Articular cartilage damage was estimated using the Osteoarthritis Research Society International (OARSI) score. The numbers of TRAP(+) osteoclasts, Osterix(+) osteoprogenitors, Osteocalcin(+) osteoblasts and expression of SOX9 were evaluated by immunohistochemistry. Results: Bone cyst group presented higher BV/TV, Tb.N and SMI at subchondral bone than non-cyst group. Furthermore, cyst subregion displayed increased BV/TV and Tb.N but lower BMD and SMI than peri-cyst subregion. Histology revealed a higher OARSI score in bone cyst group. SBC exhibited a weak relationship with BV/TV, etc. The numbers of TRAP(+) osteoclasts, Osterix(+) osteoprogenitors, Osteocalcin(+) osteoblasts and expression of SOX9, were higher in bone cyst group. Conclusion: SBCs within knee OA are characterized by focally increased bone turnover, altered bone structure and more severe articular cartilage damage. The increased bone turnover possibly contributes to altered bone structure localized in SBC areas, and thus aggravates articular cartilage degeneration. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：2174 / 2183

页数：10

共 40 条

[11]

Comparative evaluation of three semi-quantitative radiographic grading techniques for knee osteoarthritis in terms of validity and reproducibility in 1759 X-rays: report of the OARSI-OMERACT task force [J].