Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes

被引：17

作者：

Canadas, Ana ^{[1
]}

Santos, Marta ^{[1
]}

Nogueira, Augusto ^{[2
]}

Assis, Joana ^{[2
]}

Gomes, Monica ^{[2
]}

Lemos, Carolina ^{[3
,4
]}

Medeiros, Rui ^{[2
,5
,6
,7
]}

Dias-Pereira, Patricia ^{[1
]}

机构：

[1] Univ Porto, Inst Ciencias Biomed Abel Salazar, ICBAS UP, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[2] Portuguese Inst Oncol Porto IPO Porto, Mol Oncol & Viral Pathol Grp, Res Ctr CI IPOP, Porto, Portugal

[3] Univ Porto, Inst Invest & Inovacao Saude, i3S, Porto, Portugal

[4] Inst Biol Mol & Celular, UnIGENe, Porto, Portugal

[5] Fernando Pessoa Univ, Fac Hlth Sci, CEBIMED, Porto, Portugal

[6] Univ Porto, Fac Med Porto, FMUP, Porto, Portugal

[7] Portuguese League Canc, Res Dept, LPCC NRNorte, Porto, Portugal

来源：

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION | 2018年 / 30卷 / 05期

关键词：

Canine mammary tumor; polymorphisms; RAD51; risk; STK11; BREAST-CANCER; BRCA2; EXPRESSION; SUSCEPTIBILITY; CARCINOMAS; PROTEIN; LKB1;

D O I：

10.1177/1040638718789231

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

Cancer is a complex disease involving genetic and phenotypic changes. Several single nucleotide polymorphisms (SNPs) have been associated with the risk of breast cancer development in women; however, little is known regarding their influence on canine mammary tumor risk. We assessed the influence of SNPs in genes related to human breast cancer susceptibility, with respect to the risk of development of mammary tumors in dogs. Sixty-seven canine SNPs in proto-oncogenes, tumor suppressor genes, genes involved in DNA repair, and in hormonal metabolism were evaluated in 212 bitches with mammary tumors and in 161 bitches free of mammary neoplasia. A significant association with mammary neoplasia risk was identified for 2 SNPs in RAD51 (rs23623251 and rs23642734) and one SNP in the STK11 gene (rs22928814). None of the other SNPs were related to the risk of mammary tumor development. The identification of genetic profiles associated with risk of mammary neoplasia is of great importance, supporting the implementation of specific clinical management strategies in high-risk animals.

引用

页码：733 / 738

页数：6

共 23 条

[1]

Role of the human RAD51 protein in homologous recombination and double-stranded break repair [J].