Neurobehavioral assessment in the information age

被引：138

作者：

Tecott, LH

Nestler, EJ

机构：

[1] Univ Calif San Francisco, Sch Med, Ctr Neurobiol & Psychiat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Sch Med, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA

[3] Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA

[4] Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA

来源：

NATURE NEUROSCIENCE | 2004年 / 7卷 / 05期

关键词：

D O I：

10.1038/nn1225

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The elucidation of the human and mouse genomes provides new opportunities for exploring the genetic underpinnings of complex mammalian behaviors. This information also provides new windows into the pathophysiology and treatment of neuropsychiatric diseases. Optimal use of the rapidly escalating numbers of mouse lines engineered for these purposes is hindered, however, by practical and theoretical limitations of common behavioral analyses. New strategies combining automated behavioral monitoring and information technologies are currently under development in both academic and industrial settings. These hold promise, both for improving the throughput of mouse behavioral assessment and for providing new insights into the neurobiology of mammalian behavioral regulation.

引用

页码：462 / 466

页数：5