The α-aminoadipate pathway for lysine biosynthesis in fungi

被引：138

作者：

Xu, Hengyu ^{[1
]}

Andi, Babak ^{[1
]}

Qian, Jinghua ^{[1
]}

West, Ann H. ^{[1
]}

Cook, Paul F. ^{[1
]}

机构：

[1] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2006年 / 46卷 / 01期

关键词：

alpha-aminoadipate pathway; lysine biosynthesis in fungi; homocitrate synthase; Claisen condensation; alpha-aminoadipate reductase; saccharopine reductase; saccharopine dehydrogenase; pyridine nucleotide-linked amino acid oxidoreductase; antifungal drugs;

D O I：

10.1385/CBB:46:1:43

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review provides a description of the biochemistry and enzymology of the alpha-aminoadipate pathway for lysine biosynthesis in fungi. The alpha-aminoadipate pathway is unique to fungi and is thus a potential target for the rational design of antifungal drugs. The present state of knowledge of the mechanisms of the seven enzymes in the pathway is presented, as well as detailed information with respect to structures and mechanisms of homocitrate synthase, saccharopine reductase, and saccharopine dehydrogenase.

引用

页码：43 / 64

页数：22

共 134 条

[21] 2 UNLINKED LYSINE GENES (LYS9 AND LYS14) ARE REQUIRED FOR THE SYNTHESIS OF SACCHAROPINE REDUCTASE IN SACCHAROMYCES-CEREVISIAE [J].

BORELL, CW ;

URRESTARAZU, LA ;

BHATTACHARJEE, JK .

JOURNAL OF BACTERIOLOGY, 1984, 159 (01) :429-432

[22]

Broquist HP., 1971, METHODS ENZYMOL, V17B, P112

[23] THE BIOCHEMISTRY AND ENZYMOLOGY OF AMINO-ACID DEHYDROGENASES [J].

BRUNHUBER, NMW ;

BLANCHARD, JS .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1994, 29 (06) :415-467

[24]

Chen SP, 1997, J BIOL CHEM, V272, P10839

[25] KINETICS OF ENZYME-CATALYZED REACTIONS WITH 2 OR MORE SUBSTRATES OR PRODUCTS .2. INHIBITION - NOMENCLATURE AND THEORY [J].

CLELAND, WW .

BIOCHIMICA ET BIOPHYSICA ACTA, 1963, 67 (02) :173-&

[26] Homology among (βα)8 barrels:: Implications for the evolution of metabolic pathways [J].

Copley, RR ;

Bork, P .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 303 (04) :627-640

[27] BIOSYNTHESIS AND METABOLISM OF ARGININE IN BACTERIA [J].

CUNIN, R ;

GLANSDORFF, N ;

PIERARD, A ;

STALON, V .

MICROBIOLOGICAL REVIEWS, 1986, 50 (03) :314-352

[28] Lysine biosynthesis in Saccharomyces cerevisiae:: Mechanism of α-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5 [J].

Ehmann, DE ;

Gehring, AM ;

Walsh, CT .

BIOCHEMISTRY, 1999, 38 (19) :6171-6177

[29] Active site mutants of pig citrate synthase: Effects of mutations on the enzyme catalytic and structural properties [J].

Evans, CT ;

Kurz, LC ;

Remington, SJ ;

Srere, PA .

BIOCHEMISTRY, 1996, 35 (33) :10661-10672

[30] In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p [J].

Feller, A ;

Ramos, F ;

Piérard, A ;

Dubois, E .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 261 (01) :163-170

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