An evolutionarily conserved family of accessory subunits of K+ channels

被引：8

作者：

Cai, Shi-Qing ^{[1
]}

Park, Ki Ho ^{[1
]}

Sesti, Federico ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, Piscataway, NJ 08854 USA

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2006年 / 46卷 / 01期

关键词：

C; elegans; KCNE; chemotaxis; kinase;

D O I：

10.1385/CBB:46:1:91

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accessory subunits are an essential feature of voltage-gated potassium (Kv) channels. They determine trafficking to the plasma membrane, surface expression, gating, permeation, and pharmacology At least three distinct classes of accessory subunits including the KCNE family can regulate Kv channel function. KCNE genes encode integral membrane proteins with a single transmembrane domain. KCNE genes span the eukaryotic kingdom and, in mutated form, can cause acquired and congenital disease. Here we review genetic, physiological, and biophysical aspects of KCNE proteins with particular emphasis on the Caenorhabditis elegans subfamily.

引用

收藏

页码：91 / 99

页数：9

相关论文

共 78 条

[1] Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism [J].

Abbott, GW ;

Goldstein, SAN .

FASEB JOURNAL, 2002, 16 (03) :390-400

[2] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia [J].

Abbott, GW ;

Sesti, F ;

Splawski, I ;

Buck, ME ;

Lehmann, WH ;

Timothy, KW ;

Keating, MT ;

Goldstein, SAN .

CELL, 1999, 97 (02) :175-187

[3] MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis [J].

Abbott, GW ;

Butler, MH ;

Bendahhou, S ;

Dalakas, MC ;

Ptacek, LJ ;

Goldstein, SAN .

CELL, 2001, 104 (02) :217-231

[4] RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies [J].

Anantharam, A ;

Lewis, A ;

Panaghie, G ;

Gordon, E ;

McCrossan, ZA ;

Lerner, DJ ;

Abbott, GW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (14) :11739-11745

[5] KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current [J].

Angelo, K ;

Jespersen, T ;

Grunnet, M ;

Nielsen, MS ;

Klaerke, DA ;

Olesen, SP .

BIOPHYSICAL JOURNAL, 2002, 83 (04) :1997-2006

[6]

BARGMANN C, 1997, C ELEGANS 2, V1, P717

[7] K(v)LQT1 and IsK (minK) proteins associate to form the I-Ks cardiac potassium current [J].

Barhanin, J ;

Lesage, F ;

Guillemare, E ;

Fink, M ;

Lazdunski, M ;

Romey, G .

NATURE, 1996, 384 (6604) :78-80

[8] Cellular dysfunction of LQT5-minK mutants:: abnormalities of IKs, IKr and trafficking in long QT syndrome [J].

Bianchi, L ;

Shen, ZJ ;

Dennis, AT ;

Priori, SG ;

Napolitano, C ;

Ronchetti, E ;

Bryskin, R ;

Schwartz, PJ ;

Brown, AM .

HUMAN MOLECULAR GENETICS, 1999, 8 (08) :1499-1507

[9] A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans [J].

Bianchi, L ;

Kwok, SM ;

Driscoll, M ;

Sesti, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (14) :12415-12424

[10] MPS-1 is a K+ channel β-subunit and a serine/threonine kinase [J].

Cai, SQ ;

Hernandez, L ;

Wang, Y ;

Park, KH ;

Sesti, F .

NATURE NEUROSCIENCE, 2005, 8 (11) :1503-1509

← 1 2 3 4 5 6 7 8 →