An evolutionarily conserved family of accessory subunits of K+ channels

被引：8

作者：

Cai, Shi-Qing ^{[1
]}

Park, Ki Ho ^{[1
]}

Sesti, Federico ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, Piscataway, NJ 08854 USA

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2006年 / 46卷 / 01期

关键词：

C; elegans; KCNE; chemotaxis; kinase;

D O I：

10.1385/CBB:46:1:91

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accessory subunits are an essential feature of voltage-gated potassium (Kv) channels. They determine trafficking to the plasma membrane, surface expression, gating, permeation, and pharmacology At least three distinct classes of accessory subunits including the KCNE family can regulate Kv channel function. KCNE genes encode integral membrane proteins with a single transmembrane domain. KCNE genes span the eukaryotic kingdom and, in mutated form, can cause acquired and congenital disease. Here we review genetic, physiological, and biophysical aspects of KCNE proteins with particular emphasis on the Caenorhabditis elegans subfamily.

引用

收藏

页码：91 / 99

页数：9

相关论文

共 78 条

[31] Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells [J].

Heitzmann, D ;

Grahammer, F ;

von Hahn, T ;

Schmitt-Gräff, A ;

Romeo, E ;

Nitschke, R ;

Gerlach, U ;

Lang, HJ ;

Verrey, F ;

Barhanin, J ;

Warth, R .

JOURNAL OF PHYSIOLOGY-LONDON, 2004, 561 (02) :547-557

[32] Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics [J].

Isbrandt, D ;

Friederich, P ;

Solth, A ;

Haverkamp, W ;

Ebneth, A ;

Borggrefe, M ;

Funke, H ;

Sauter, K ;

Breithardt, G ;

Pongs, O ;

Schulze-Bahr, E .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2002, 80 (08) :524-532

[33] KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts [J].

Jiang, M ;

Zhang, M ;

Tang, DG ;

Clemo, HF ;

Liu, J ;

Holwitt, D ;

Kasirajan, V ;

Pond, AL ;

Wettwer, E ;

Tseng, GN .

CIRCULATION, 2004, 109 (14) :1783-1788

[34] Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel [J].

Kurokawa, J ;

Chen, L ;

Kass, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :2122-2127

[35] TEA+-sensitive KCNQ1 constructs reveal pore-independent access to KCNE1 in assembled IKs channels [J].

Kurokawa, J ;

Motoike, HK ;

Kass, RS .

JOURNAL OF GENERAL PHYSIOLOGY, 2001, 117 (01) :43-52

[36] MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating [J].

Lewis, A ;

McCrossan, ZA ;

Abbott, GW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (09) :7884-7892

[37] Mutant MiRP1 subunits modulate HERG K+ channel gating:: a mechanism for pro-arrhythmia in long QT syndrome type 6 [J].

Lu, Y ;

Mahaut-Smith, MP ;

Huang, CLH ;

Vandenberg, JI .

JOURNAL OF PHYSIOLOGY-LONDON, 2003, 551 (01) :253-262

[38]

Lundquist Andrew L, 2005, J Mol Cell Cardiol, V38, P277, DOI 10.1016/j.yjmcc.2004.11.012

[39] Requirement of a macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel [J].

Marx, SO ;

Kurokawa, J ;

Reiken, S ;

Motoike, H ;

D'Armiento, J ;

Marks, AR ;

Kass, RS .

SCIENCE, 2002, 295 (5554) :496-499

[40]

McCrossan ZA, 2003, J NEUROSCI, V23, P8077

← 1 2 3 4 5 6 7 8 →