Evidence for a trigonal bipyramidal intermediate during nucleophilic substitution at a sulfonyl centre and for a sulfonylium cation in the acid catalysed reaction

被引：6

作者：

Baxter, NJ ^{[1
]}

Laws, AP ^{[1
]}

Rigoreau, L ^{[1
]}

Page, MI ^{[1
]}

机构：

[1] UNIV HUDDERSFIELD, DEPT CHEM & BIOL SCI, HUDDERSFIELD HD1 3DH, W YORKSHIRE, ENGLAND

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 21期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1039/a705416e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The rate of alkaline hydrolysis of a substituted beta-sultam shows a dominant term second-order in hydroxide ion, clearly indicating the reversible formation of a monoanionic trigonal bipyramidal intermediate; substituent effects and kinetic parameters for the acid catalysed hydrolysis are indicative of the formation of a sulfonylium ion intermediate.

引用

页码：2037 / 2038

页数：2

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