Application of genome-wide single nucleotide polymorphism typing: Simple association and beyond

被引：74

作者：

Gibbs, J. Raphael

Singleton, Andrew ^{[1
]}

机构：

[1] NIA, Mol Genet Unit, NIH, Porter Neurosci Res Ctr, Bethesda, MD 20892 USA

[2] NIA, Computat Biol Core, NIH, Porter Neurosci Res Ctr, Bethesda, MD 20892 USA

来源：

PLOS GENETICS | 2006年 / 2卷 / 10期

关键词：

D O I：

10.1371/journal.pgen.0020150

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

T he International HapMap Project and the arrival of technologies that type more than 100,000 SNPs in a single experiment have made genome-wide single nucleotide polymorphism (GW-SNP) assay a realistic endeavor. This has sparked considerable debate regarding the promise of GW-SNP typing to identify genetic association in disease. As has already been shown, this approach has the potential to localize common genetic variation underlying disease risk. The data provided from this technology also lends itself to several other lines of investigation; autozygosity mapping in consanguineous families and outbred populations, direct detection of structural variation, admixture analysis, and other population genetic approaches. In this review we will discuss the potential uses and practical application of GW-SNP typing including those above and beyond simple association testing.

引用

页码：1511 / 1517

页数：7

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