An Environmental DNA-Derived Type II Polyketide Biosynthetic Pathway Encodes the Biosynthesis of the Pentacyclic Polyketide Erdacin

被引：33

作者：

King, Ryan W. ^{[1
]}

Bauer, John D. ^{[1
]}

Brady, Sean F. ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Genetically Encoded Small Mol, New York, NY 10065 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 34期

关键词：

biosynthesis; DNA; metagenomics; natural products; polyketides; GENE CLUSTERS; NATURAL-PRODUCTS; SYNTHASE GENES; STREPTOMYCES-COELICOLOR; HETEROLOGOUS EXPRESSION; PROKARYOTIC DIVERSITY; SOIL; LIBRARIES; MICROORGANISMS; BACTERIA;

D O I：

10.1002/anie.200901209

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A down to earth approach: Environmental (from desert soil) DNA derived cosmid clones containing type II polyketide synthase genes were screened for their ability to produce clone-specific metabolites in Streptomyces. One of the Streptomyces recombinants produces erdacin (1), a polyketide with a previously unknown pentacyclic structure. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6257 / 6261

页数：5

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