AMP-activated protein kinase: An emerging target for ginseng

被引：69

作者：

Jeong, Kyong Ju ^{[1
]}

Kim, Go Woon ^{[1
]}

Chung, Sung Hyun ^{[1
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Dept Pharmacol & Clin Pharm, Seoul 130701, South Korea

来源：

JOURNAL OF GINSENG RESEARCH | 2014年 / 38卷 / 02期

关键词：

AMPK; cancer; ginsenosides; metabolic disease; Panax ginseng; HEPATIC GLUCOSE-PRODUCTION; KOREAN RED GINSENG; HEPG2; CELLS; PANAX-GINSENG; RAT-LIVER; ERECTILE DYSFUNCTION; LIPID-ACCUMULATION; SIGNALING PATHWAY; CELLULAR-ENERGY; FATTY LIVER;

D O I：

10.1016/j.jgr.2013.11.014

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of cellular energy. Once activated, it switches on catabolic pathways generating adenosine triphosphate (ATP), while switching off biosynthetic pathways consuming ATP. Pharmacological activation of AMPK by metformin holds a therapeutic potential to reverse metabolic abnormalities such as type 2 diabetes and nonalcoholic fatty liver disease. In addition, altered metabolism of tumor cells is widely recognized and AMPK is a potential target for cancer prevention and/or treatment. Panax ginseng is known to be useful for treatment and/or prevention of cancer and metabolic diseases including diabetes, hyperlipidemia, and obesity. In this review, we discuss the ginseng extracts and ginsenosides that activate AMPK, we clarify the various mechanisms by which they achieve this, and we discuss the evidence that shows that ginseng or ginsenosides might be useful in the treatment and/or prevention of metabolic diseases and cancer. Copyright (C) 2013, The Korean Society of Ginseng, Published by Elsevier. All rights reserved.

引用

页码：83 / 88

页数：6

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