Comparison of the photodynamic action of methylene blue and zinc phthalocyanine on TG-180 tumoral cells

被引：3

作者：

de Miranda, JA ^{[1
]}

Machado, AED ^{[1
]}

de Oliveira, CA ^{[1
]}

机构：

[1] Univ Fed Uberlandia, Inst Quim, GFQL, Lab Fotoquim, BR-38400089 Uberlandia, MG, Brazil

来源：

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES | 2002年 / 6卷 / 01期

关键词：

efficiency; photodynamic agents; cell killing;

D O I：

10.1142/S1088424602000075

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The efficiency of zinc phthalocyanine and methylene blue (CI 52015) in compromise the viability of TG 180 malignant cells by photodynamic action, was compared by counting the number of killed cells. The results show that, under the observed experimental conditions, zinc phthalocyanine (ZnPc) is at least two times more efficient than methylene blue (MB), and possesses a very low citotoxicity and high capacity to penetrate the cellular membrane. Quenching experiments using beta-carothene evidence the importance of a type II mechanism during cell inactivation by ZnPc. Copyright (C) 2002 Society of Porphyrins & Phthalocyanines.

引用

页码：43 / 49

页数：7

共 34 条

[1]

ARDOIN P, 1967, CR SOC BIOL, V161, P117

[2] THE EFFECTS OF AGGREGATION, PROTEIN-BINDING AND CELLULAR INCORPORATION ON THE PHOTOPHYSICAL PROPERTIES OF BENZOPORPHYRIN DERIVATIVE MONOACID RING-A (BPDMA) [J].

AVELINE, BM ;

HASAN, T ;

REDMOND, RW .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1995, 30 (2-3) :161-169

[3] ADVANCES IN PHOTOCHEMICAL APPROACHES FOR BLOOD STERILIZATION [J].

BENHUR, E ;

HOROWITZ, B .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1995, 62 (03) :383-388

[4] EVALUATION OF SULFONATED ALUMINUM PHTHALOCYANINES FOR USE IN PHOTOCHEMOTHERAPY - CELLULAR UPTAKE STUDIES [J].

BERG, K ;

BOMMER, JC ;

MOAN, J .

CANCER LETTERS, 1989, 44 (01) :7-15

[5]

BURDON RH, 1990, LAB TECHNIQUES BIOCH

[6] THE PHOTOPHYSICAL PROPERTIES OF A RUTHENIUM-SUBSTITUTED PHTHALOCYANINE [J].

CHARLESWORTH, P ;

TRUSCOTT, TG ;

BROOKS, RC ;

WILSON, BC .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1994, 26 (03) :277-282

[7]

DEMOURA JCV, 1998, NONANTIBIOTICS

[8] Photodynamic therapy [J].

Dougherty, TJ ;

Gomer, CJ ;

Henderson, BW ;

Jori, G ;

Kessel, D ;

Korbelik, M ;

Moan, J ;

Peng, Q .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (12) :889-905

[9] A chemical dosimeter for the determination of the photodynamic activity of photosensitizers [J].

Fischer, F ;

Graschew, G ;

Sinn, HJ ;

Maier-Borst, W ;

Lorenz, WJ ;

Schlag, PM .

CLINICA CHIMICA ACTA, 1998, 274 (01) :89-104

[10]

FRIMER AA, 1989, SINGLET OXYGEN

← 1 2 3 4 →