T helper cell polarisation in coeliac disease: any (T-)bet?

被引：5

作者：

Holtmann, MH ^{[1
]}

Neurath, MF ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Med Clin 1, Immunol Lab, Dept Med 1, D-55131 Mainz, Germany

来源：

GUT | 2004年 / 53卷 / 08期

关键词：

D O I：

10.1136/gut.2003.038232

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Recent data strongly support the view that coeliac disease is a Th1 mediated inflammatory disease as both interferon gamma production and T-bet levels in gut infiltrating cells are upregulated.

引用

页码：1065 / 1067

页数：3

共 37 条

[31] Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells [J].

Szabo, SJ ;

Sullivan, BM ;

Stemmann, C ;

Satoskar, AR ;

Sleckman, BP ;

Glimcher, LH .

SCIENCE, 2002, 295 (5553) :338-342

[32] Molecular mechanisms regulating Th1 immune responses [J].

Szabo, SJ ;

Sullivan, BM ;

Peng, SL ;

Glimcher, LH .

ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :713-758

[33]

TARGAN SR, 1995, J IMMUNOL, V154, P664

[34]

THOMAS C, 1945, CLASSIC DESCRIPTIONS, P600

[35]

van de Wal Y, 1998, J IMMUNOL, V161, P1585

[36] Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease [J].

Ventura, A ;

Magazzù, G ;

Greco, L .

GASTROENTEROLOGY, 1999, 117 (02) :297-303

[37] The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells [J].

Zheng, WP ;

Flavell, RA .

CELL, 1997, 89 (04) :587-596

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