Lumen Gain and Restoration of Pulsatility After Implantation of a Bioresorbable Vascular Scaffold in Porcine Coronary Arteries

被引：73

作者：

Lane, Jennifer P. ^{[1
]}

Perkins, Laura E. L. ^{[1
]}

Sheehy, Alexander J. ^{[1
]}

Pacheco, Erica J. ^{[2
]}

Frie, Michael P. ^{[3
]}

Lambert, Byron J. ^{[1
]}

Rapoza, Richard J. ^{[1
]}

Virmani, Renu ^{[2
]}

机构：

[1] Abbott Vasc, Santa Clara, CA USA

[2] CVPath Inc, Gaithersburg, MD USA

[3] Amer Preclin Serv, Minneapolis, MN USA

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2014年 / 7卷 / 06期

关键词：

animals; bioresorbable scaffold; coronary artery imaging; pathology; DRUG-ELUTING STENTS; INTRAVASCULAR ULTRASOUND; SHEAR-STRESS; ENDOTHELIAL DYSFUNCTION; IMAGING OUTCOMES; BARE-METAL; 2ND-GENERATION; RESTENOSIS; PATHOLOGY; DISEASE;

D O I：

10.1016/j.jcin.2013.11.024

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objectives Using intravascular ultrasound (IVUS) and histomorphometry, this study sought to evaluate the potential of nonatherosclerotic porcine coronary arteries to undergo progressive lumen gain and a return of pulsatility after implantation with an everolimus-eluting bioresorbable vascular scaffold (BVS). Background Unique benefits such as lumen gain and restored vasomotion have been demonstrated clinically after treatment with BVS; however, a more rigorous demonstration of these benefits with a randomized clinical trial has not yet been conducted. Methods Seventy nonatherosclerotic swine received 109 everolimus-eluting BVS and 70 everolimus-eluting metal stents randomized among the main coronary arteries. Arteries were evaluated in vivo by angiography and IVUS and post-mortem by histomorphometry at time points from 1 to 42 months. Results From 1 to 6 months, both BVS- and everolimus-eluting metal stent-implanted arteries demonstrated stable lumen areas (LAs). From 12 months to 42 months, there was a progressive increase in the LA of arteries implanted with a BVS as assessed by histomorphometry and IVUS. This lumen gain in the implanted segment corresponded to an increase in the reference vessel LA. Normalization in the in-segment LA (LA: reference vessel LA) was observed qualitatively by angiography and quantitatively by IVUS. Additionally, BVS-implanted arteries demonstrated restored in-segment pulsatility on the basis of IVUS assessment of the differences in the mid-scaffold area between end-diastole to end-systole. Conclusions Starting at 12 months, BVS-implanted porcine coronary arteries underwent progressive lumen gain and showed restored pulsatility. These benefits demonstrated preclinically may translate into improvements in long-term clinical outcomes for patients treated with BVS compared with conventional drug-eluting stents. (C) 2014 by the American College of Cardiology Foundation

引用

页码：688 / 695

页数：8

共 33 条

[1]

[Anonymous], 2011, Guide for the care and use of laboratory animals

[2]

Vascular Compliance Changes of the Coronary Vessel Wall After Bioresorbable Vascular Scaffold Implantation in the Treated and Adjacent Segments [J].