Regulatory T cells

被引:188
作者
Beissert, Stefan
Schwarz, Agatha
Schwarz, Thomas
机构
[1] Univ Kiel, Dept Dermatol, D-24105 Kiel, Germany
[2] Univ Munster, Dept Dermatol, D-4400 Munster, Germany
关键词
D O I
10.1038/sj.jid.5700004
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Immunologic self-tolerance is critically dependent on the induction but also on the downregulation of immune responses. Though ignored and neglected for many years, suppressor T cells, now renamed regulatory T cells (Tregs), play an important role in the negative regulation of immune responses. Several subsets of Tregs have been described. Naturally occurring CD4(+) CD25(+) Tregs are important in the prevention of autoimmune diseases. Type 1 Tregs, another subtype of Treg that is inducible, exert their suppressive activity primarily via the release of IL-10. Detailed knowledge about the phenotype and mode of action of these cells will significantly increase our understanding of the pathogenesis of autoimmune diseases and will also help to identify new therapeutic strategies.
引用
收藏
页码:15 / 24
页数:10
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