Type III IFNs: New layers of complexity in innate antiviral immunity

被引：77

作者：

Ank, Nina ^{[1
]}

Paludan, Soren R. ^{[1
]}

机构：

[1] Univ Aarhus, Inst Med Microbiol & Immunol, DK-8000 Aarhus C, Denmark

来源：

BIOFACTORS | 2009年 / 35卷 / 01期

关键词：

Type III interferon; virus infections innate immunity; C VIRUS-REPLICATION; HERPES-SIMPLEX-VIRUS; ANTITUMOR-ACTIVITY; VIRAL-INFECTIONS; IN-VIVO; LAMBDA; INTERFERONS; CELLS; RECOGNITION; CYTOKINES;

D O I：

10.1002/biof.19

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokines are small secreted molecules, which mediated cross-talk between cells involved in the immune response Interferon's (IFN)s, constitute a class of cytokines antiviral activities, and the type I IFNs have been ascribed particularly important roles in, the innate antiviral response Type III IFNs.(also known as IFN-lambda or interleukin 28/29) represent a class of novel cytokines with biological activities similar to the type I IFNs, but seem to have a more specialized role in antiviral defense by exerting host-protection primarily at epithelial surfaces. In this review, we describe the current knowledge on the role of type III IFNS in antiviral defense.(C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 1, January/February 2009, Pages 82-87. E-mail: srp@microbiology.au.dk

引用

页码：82 / 87

页数：6

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