Nuclear relaxation studies in ligand-macromolecule affinity index determinations

被引：29

作者：

Rossi, C ^{[1
]}

Donati, A ^{[1
]}

Bonechi, C ^{[1
]}

Corbini, G ^{[1
]}

Rappuoli, R ^{[1
]}

Dreassi, E ^{[1
]}

Corti, P ^{[1
]}

机构：

[1] UNIV SIENA,DEPT PHARMACEUT CHEM,I-53100 SIENA,ITALY

来源：

CHEMICAL PHYSICS LETTERS | 1997年 / 264卷 / 1-2期

关键词：

D O I：

10.1016/S0009-2614(96)01296-1

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An 'affinity index', representing the global affinity between a ligand and a biomacromolecular receptor, is proposed. It is determined as the slope of the linear relations between Delta R(1)(SE) and the receptor concentration and has the advantage of providing a measure of the ligand-biomacromolecule global affinity which is independent of the number of interaction sites. The method was applied to the calculation of the lamotrigine-albumin affinity index.

引用

页码：205 / 209

页数：5

共 16 条

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